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Targeted Allele Detail
Symbol: Yes1tm1Sor
Name: YES proto-oncogene 1, Src family tyrosine kinase; targeted mutation 1, Philippe Soriano
MGI ID: MGI:1857269
Synonyms: p62YesKO, yes-, yes neo
Gene: Yes1  Location: Chr5:32768515-32844401 bp, + strand  Genetic Position: Chr5, 17.33 cM
Germline Transmission:  Earliest citation of germline transmission: J:20346
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe yes gene was disrupted by insertion of a neomycin cassette into exon 7, which encodes the beginning of the kinase domain. A partial protein product has been reported in some cell types (see J:54973). (J:20346)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 6 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Yes1 Mutation:  132 strains or lines available
Original:  J:20346 Stein PL, et al., Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice. Genes Dev. 1994 Sep 1;8(17):1999-2007
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory