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Twist1tm1Bhr
Targeted Allele Detail
Nomenclature
Symbol: Twist1tm1Bhr
Name: twist basic helix-loop-helix transcription factor 1; targeted mutation 1, Richard R Behringer
MGI ID: MGI:1857265
Synonyms: twist-1-, twist1del
Gene: Twist1  Location: Chr12:33957671-33959817 bp, + strand  Genetic Position: Chr12, 14.81 cM, cytoband B-C1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:24349
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (knock-out)
Mutations:    Insertion, Intragenic deletion
    A neomycin selection cassette replaced exon 1, which contains the entire coding region. (J:24349)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 224 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Twist1 Mutation:  8 strains or lines available
References
Original:  J:24349 Chen ZF, et al., twist is required in head mesenchyme for cranial neural tube morphogenesis. Genes Dev. 1995 Mar 15;9(6):686-99
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory