About   Help   FAQ
Tnfrsf1btm1Mwm
Targeted Allele Detail
Summary
Symbol: Tnfrsf1btm1Mwm
Name: tumor necrosis factor receptor superfamily, member 1b; targeted mutation 1, Mark Moore
MGI ID: MGI:1857262
Synonyms: p75-, p75TNFR2-, TNF-R2-, TNFR20, Tnfr2tm1Mwm, TNFR II -, TNFRp75-
Gene: Tnfrsf1b  Location: Chr4:144940033-144973440 bp, - strand  Genetic Position: Chr4, 78.17 cM
Alliance: Tnfrsf1btm1Mwm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:21815
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 2, which codes for the signal peptide region, was disrupted by the insertion of a neomycin cassette. To confirm that the gene was correctly targeted, mice were challenged with lipopolysaccharide (LPS) which results in shedding of the Tnfrsf1b extracellular domian in wild-type mice. No soluble Tnfrsf1b was detected in the serum of homozygous mutant animals. (J:21815)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Mice Carrying this Mutation: 104036 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf1b Mutation:  41 strains or lines available
References
Original:  J:21815 Erickson SL, et al., Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice. Nature. 1994 Dec 8;372(6506):560-3
All:  189 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory