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Targeted Allele Detail
Symbol: Tnfrsf1btm1Mwm
Name: tumor necrosis factor receptor superfamily, member 1b; targeted mutation 1, Mark Moore
MGI ID: MGI:1857262
Synonyms: p75-, p75TNFR2-, TNF-R2-, TNFR20, Tnfr2tm1Mwm, TNFR II -, TNFRp75-
Gene: Tnfrsf1b  Location: Chr4:144940033-144973440 bp, - strand  Genetic Position: Chr4, 78.17 cM
Germline Transmission:  Earliest citation of germline transmission: J:21815
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsExon 2, which codes for the signal peptide region, was disrupted by the insertion of a neomycin cassette. To confirm that the gene was correctly targeted, mice were challenged with lipopolysaccharide (LPS) which results in shedding of the Tnfrsf1b extracellular domian in wild-type mice. No soluble Tnfrsf1b was detected in the serum of homozygous mutant animals. (J:21815)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 103958 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf1b Mutation:  26 strains or lines available
Original:  J:21815 Erickson SL, et al., Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice. Nature. 1994 Dec 8;372(6506):560-3
All:  176 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory