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Targeted Allele Detail
Symbol: Tnfrsf1atm1Mak
Name: tumor necrosis factor receptor superfamily, member 1a; targeted mutation 1, Tak Mak
MGI ID: MGI:1857261
Synonyms: p55-, Pfeffer Tnfrsf1a-, TNF-alphaRI-, TNFR-, TNF-R1-, TNFR1-, TNFR1/p55-, TNFRp55-, Tnfrsf1a-, Tnfrsf1atm1Mak
Gene: Tnfrsf1a  Location: Chr6:125326686-125339446 bp, + strand  Genetic Position: Chr6, 59.32 cM
Germline Transmission:  Earliest citation of germline transmission: J:4753
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin cassette was inserted at position 535 of the coding sequence. A radioligand binding assay demonstrated that no functional protein was present on the cell surface of splenocytes derived from homozygous mice. (J:4753, J:29283)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 24 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf1a Mutation:  36 strains or lines available
Original:  J:4753 Pfeffer K, et al., Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell. 1993 May 7;73(3):457-67
All:  304 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.19
The Jackson Laboratory