Tcra^tm1Mom
Targeted Allele Detail

Summary

• Symbol: Tcra^tm1Mom
• Name: T cell receptor alpha chain; targeted mutation 1, Peter Mombaerts
• MGI ID: MGI:1857255
• Synonyms: alpha^-, C-alpha-, TCR alpha-, TCRalpha-, TCR alpha⁰, TCRalpha KO, TCR Calpha^-, TCR^mini
• Gene: Tcra Location: Chr14:52665424-54461655 bp, + strand Genetic Position: Chr14, cytoband D1-D2

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:3206
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette was used to disrupt exon 1, which encodes the majority of the extracellular domain. The targeting event was confirmed by Southern analysis. (J:3206, J:113136, J:126027)

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 6 strains available Cell Lines: 0 lines available
• Carrying any Tcra Mutation: 98 strains or lines available

References

• Original: J:3206 Mombaerts P, et al., Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages [published erratum appears in Nature 1992 Dec 3;360(6403):491]. Nature. 1992 Nov 19;360(6401):225-31
• All: 406 reference(s)