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Tcratm1Mom
Targeted Allele Detail
Nomenclature
Symbol: Tcratm1Mom
Name: T cell receptor alpha chain; targeted mutation 1, Peter Mombaerts
MGI ID: MGI:1857255
Synonyms: alpha-, C-alpha-, TCR alpha-, TCRalpha-, TCR alpha0, TCRalpha KO, TCR Calpha-, TCRmini
Gene: Tcra  Location: Chr14:52427967-54224198 bp, + strand  Genetic Position: Chr14, cytoband D1-D2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:3206
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neo cassette was used to disrupt exon 1, which encodes the majority of the extracellular domain. The targeting event was confirmed by Southern analysis. (J:3206, J:113136, J:126027)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Tcra Mutation:  89 strains or lines available
References
Original:  J:3206 Mombaerts P, et al., Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages [published erratum appears in Nature 1992 Dec 3;360(6403):491]. Nature. 1992 Nov 19;360(6401):225-31
All:  306 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory