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Targeted Allele Detail
Symbol: Tap1tm1Arp
Name: transporter 1, ATP-binding cassette, sub-family B (MDR/TAP); targeted mutation 1, Philip Ashton-Rickardt
MGI ID: MGI:1857253
Synonyms: Abcb2tm1Arp, TAP-, TAP-1-, TAP1-
Gene: Tap1  Location: Chr17:34406530-34416199 bp, + strand  Genetic Position: Chr17, 17.98 cM
Germline Transmission:  Earliest citation of germline transmission: J:3524
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 7kb region of the wild-type locus (which made up 80% of the protein coding region) was replaced by a neomycin resistance cassette. (J:3524)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Tap1 Mutation:  30 strains or lines available
Original:  J:3524 Van Kaer L, et al., TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells. Cell. 1992 Dec 24;71(7):1205-14
All:  157 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory