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Stat5atm1Mam
Targeted Allele Detail
Nomenclature
Symbol: Stat5atm1Mam
Name: signal transducer and activator of transcription 5A; targeted mutation 1, Lothar Hennighausen
MGI ID: MGI:1857249
Synonyms: Stat5a-
Gene: Stat5a  Location: Chr11:100859351-100885169 bp, + strand  Genetic Position: Chr11, 63.77 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64278
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe promoter sequence, an untranslated exon, and two coding exons were replaced by a neomycin selection cassette. Western blot analysis of extracts immunoprecipitated from mammary tissue of homozygous mutant mice showed an absence of encoded protein. (J:64278)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 439944 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Stat5a Mutation:  6 strains or lines available
References
Original:  J:64278 Liu X, et al., Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev. 1997 Jan 15;11(2):179-86
All:  35 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory