Selp^tm1Bay
Targeted Allele Detail

Summary

• Symbol: Selp^tm1Bay
• Name: selectin, platelet; targeted mutation 1, Baylor College of Medicine
• MGI ID: MGI:1857244
• Synonyms: CD62ELP^-, CD62P^-, P-, P-sel^-, P-selectin^-
• Gene: Selp Location: Chr1:163942833-163977595 bp, + strand Genetic Position: Chr1, 71.42 cM
• Alliance: Selp^tm1Bay page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:24239
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene was inserted in the reverse orientation to delete a 4.5kb region containing exons 3 through 5. RT-PCR analysis of lung RNA isolated from homozygous mutant mice showed a transcript 682 base pairs shorter than normal. Immunohistochemical staining showed a lack of encoded protein on both endothelium and platelets. (J:24239)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Selp^tm1Bay

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Selp Mutation: 56 strains or lines available

References

• Original: J:24239 Bullard DC, et al., P-selectin/ICAM-1 double mutant mice: acute emigration of neutrophils into the peritoneum is completely absent but is normal into pulmonary alveoli [see comments]. J Clin Invest. 1995 Apr;95(4):1782-8
• All: 137 reference(s)