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Ptgs2tm1Jed
Targeted Allele Detail
Nomenclature
Symbol: Ptgs2tm1Jed
Name: prostaglandin-endoperoxide synthase 2; targeted mutation 1, Joe E Dinchuk
MGI ID: MGI:1857239
Synonyms: Cox-2-, COX-2-, COX2-, Ptgs2-
Gene: Ptgs2  Location: Chr1:150100031-150108227 bp, + strand  Genetic Position: Chr1, 63.84 cM, cytoband H1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:29974
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 1.8 kb genomic fragment containing exon 1 and the transcription and translation start sites was replaced with a neomycin selection cassette. Northern blot analysis on RNA derived from embryonic fibroblasts derived from homozygous embryos demonstrated that no detectable transcript was produced from this allele. (J:29974)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptgs2 Mutation:  33 strains or lines available
References
Original:  J:29974 Dinchuk JE, et al., Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature. 1995 Nov 23;378(6555):406-9
All:  82 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory