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Targeted Allele Detail
Symbol: Abcb4tm1Bor
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 4; targeted mutation 1, Piet Borst
MGI ID: MGI:1857236
Synonyms: mdr2-, Mdr2ko, mdr2neo1, Pgy2tm1Bor
Gene: Abcb4  Location: Chr5:8893717-8959231 bp, + strand  Genetic Position: Chr5, 3.43 cM
Germline Transmission:  Earliest citation of germline transmission: J:15531
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced a genomic fragment containing exons 1 and 2. The translation initiation site is in exon 2. RNase proteiction assays indicated that mutant truncated transcripts are produced from this allele that contain exons 3-6 or 4-6. (J:15531)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Abcb4 Mutation:  21 strains or lines available

Phenotypic Similarity to Human Syndrome: Hepatic Osteodystrophy associated with Chronic Cholestatic Liver Disease J:199949.

Original:  J:15531 Smit JJ, et al., Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell. 1993 Nov 5;75(3):451-62
All:  62 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.08
The Jackson Laboratory