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Oxttm1Wsy
Targeted Allele Detail
Nomenclature
Symbol: Oxttm1Wsy
Name: oxytocin; targeted mutation 1, W Scott Young III
MGI ID: MGI:1857234
Synonyms: OT-, OTKO -
Gene: Oxt  Location: Chr2:130576173-130577054 bp, + strand  Genetic Position: Chr2, 63.24 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:36926
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted using neomycin resistance cassette. The vector replaced sequences encoding the last two exons. Hybridization histochemistry and immunocytochemistry were used to demonstrate the lack of transcript and protein in homozygous mutant animals. (J:36926)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Oxt Mutation:  14 strains or lines available
References
Original:  J:36926 Young WS 3rd, et al., Deficiency in mouse oxytocin prevents milk ejection, but not fertility or parturition. J Neuroendocrinol. 1996 Nov;8(11):847-53
All:  28 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory