Nos1tm1Plh
Targeted Allele Detail
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Symbol: |
Nos1tm1Plh |
Name: |
nitric oxide synthase 1, neuronal; targeted mutation 1, Paul L Huang |
MGI ID: |
MGI:1857227 |
Synonyms: |
alphaNOS1, Kn, N2KO, nNOS-, nNOS-, nNOS KO, NOSdelta |
Gene: |
Nos1 Location: Chr5:118004904-118096905 bp, + strand Genetic Position: Chr5, 57.29 cM, cytoband F
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Alliance: |
Nos1tm1Plh page
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Renal tubular apoptosis, regeneration, glomerulosclerosis and glomerular thrombus formation in Nos1tm1Plh/Nos1tm1Plh Nos2tm1Mrl/Nos2tm1Mrl Nos3tm1Plh/Nos3tm1Plh mice
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:16390
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin cassette replaced exon 1. This exon encodes the initiation site and amino acids 1 - 159 of the protein. Northern blots of brain homogenates from homozygous mutant mice showed no detectable mRNA. Western blots of brain homogenates from homozygous mutant mice showed no detectable protein. However, splice variants are expressed and variable low levels of NOS activity are seen in the brain.
(J:16390, J:31846, J:62375)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:16390 Huang PL, et al., Targeted disruption of the neuronal nitric oxide synthase gene. Cell. 1993 Dec 31;75(7):1273-86 |
All: |
292 reference(s) |
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