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Targeted Allele Detail
Symbol: Myf6tm1Wb
Name: myogenic factor 6; targeted mutation 1, Barbara Wold
MGI ID: MGI:1857220
Synonyms: MRF4bh1
Gene: Myf6  Location: Chr10:107328709-107330584 bp, - strand  Genetic Position: Chr10, 55.96 cM
Germline Transmission:  Earliest citation of germline transmission: J:29279
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsReplacement of DNA sequences encoding codons 40-173 with a neomycin cassette. This mutation eliminates the helix-loop-helix domain of the protein. Expression of Myf5 is seen at E8, however by E10, it is lower and remains lower. (J:29279)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 118 assay results
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Myf6 Mutation:  13 strains or lines available
Studies have shown that Myf6 may regulate Myf5 expression by a cis-acting mechanism and that the skeletal abnormalities seen in Myf6 homozygotes may result from a decrease or lack of Myf5 expression (J:29279, J:42453). This allele (Myf6tm1Wb) exhibits normal Myf5 expression at E8 but by E10, expression is reduced (J:29279).
Original:  J:29279 Patapoutian A, et al., Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome. Development. 1995 Oct;121(10):3347-58
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory