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Targeted Allele Detail
Symbol: Myf5tm1Jae
Name: myogenic factor 5; targeted mutation 1, Rudolf Jaenisch
MGI ID: MGI:1857219
Synonyms: Myf-5 (-), Myf5Jae, Myf-5m1
Gene: Myf5  Location: Chr10:107482908-107486134 bp, - strand  Genetic Position: Chr10, 55.95 cM
Germline Transmission:  Earliest citation of germline transmission: J:3013
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    A PGK-neomycin cassette was inserted into exon 1 of the gene, disrupting the reading frame. (J:3013)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 207 assay results
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Myf5 Mutation:  5 strains or lines available
Mice homozygous for Myf6 mutations lack or show reduced Myf5 expression and exhibit phenotypes seen in Myf5tm1Jae homozygotes. Studies have shown that Myf6 may regulate Myf5 expression by a cis-acting mechanism and that the skeletal abnormalities seen in Myf6 homozygotes may result from a decrease or lack of Myf5 expression (J:24360, J:31636).
Original:  J:3013 Braun T, et al., Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death. Cell. 1992 Oct 30;71(3):369-82
All:  37 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory