About   Help   FAQ
Lifrtm1Imx
Targeted Allele Detail
Nomenclature
Symbol: Lifrtm1Imx
Name: LIF receptor alpha; targeted mutation 1, Immunex
MGI ID: MGI:1857213
Synonyms: LIFR -
Gene: Lifr  Location: Chr15:7090615-7197489 bp, + strand  Genetic Position: Chr15, 3.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:25253
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
    A lacZ/neomycin cassette replaced the ATG start codon in the targeted construct. (J:25253)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Mice Carrying this Mutation: 14 assay results
In Structures Affected by this Mutation: 16 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lifr Mutation:  9 strains or lines available
References
Original:  J:25253 Ware CB, et al., Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death. Development. 1995 May;121(5):1283-99
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/04/2019
MGI 6.14
The Jackson Laboratory