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Targeted Allele Detail
Symbol: Itgb2tm1Bay
Name: integrin beta 2; targeted mutation 1, Baylor College of Medicine
MGI ID: MGI:1857208
Synonyms: CD18-, CD18hypo, CD18low, Itgb2hypo
Gene: Itgb2  Location: Chr10:77530252-77565708 bp, + strand  Genetic Position: Chr10, 39.72 cM
Clinical features and histopathology of psoriasiform skin disease in Itgb2tm1Bay/Itgb2tm1Bay mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:13599
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Hypomorph)
Mutation:    Insertion
Mutation detailsAn insertion mutation that duplicates exons 2 and 3 with interruption of one copy of exon 3 with a neomycin cassette. This is not a null mutation but rather a hypomorph expressing very low levels of ITGB2 protein. (J:13599)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itgb2 Mutation:  9 strains or lines available
Homozygous or trans heterozgous mice (Itgb2tm1Bay / Itgb2tm2Bay) on a mixed background that includes the strain PL/J and trans heterozygous mice on a congenic PL/J background display Phenotypic Similarity to Human Syndrome: Psoriasis. However, mice on backgrounds that do not include PL/J do not display psoriasis. (J:32126, J:84126, J:109598, J:207148)

Original:  J:13599 Wilson RW, et al., Gene targeting yields a CD18-mutant mouse for study of inflammation. J Immunol. 1993 Aug 1;151(3):1571-8
All:  47 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory