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Irf1tm1Mak
Targeted Allele Detail
Nomenclature
Symbol: Irf1tm1Mak
Name: interferon regulatory factor 1; targeted mutation 1, Tak Mak
MGI ID: MGI:1857205
Synonyms: IRF-1-
Gene: Irf1  Location: Chr11:53770014-53778374 bp, + strand  Genetic Position: Chr11, 32.0 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64286
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a 1.2 kb region of the gene, which encodes for amino acids 63 - 223, deleting part of the DNA-binding domain of the protein. (J:64286)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Irf1 Mutation:  6 strains or lines available
References
Original:  J:64286 Matsuyama T, et al., Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development. Cell. 1993 Oct 8;75(1):83-97
All:  105 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory