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Targeted Allele Detail
Symbol: Il12btm1Jm
Name: interleukin 12b; targeted mutation 1, Jeanne Magram
MGI ID: MGI:1857201
Synonyms: IL-12-, Il-12/23p40 KO, Il12b-, IL-12btm1 Jm, IL-12KO, IL-12 p40-, IL-12p40-, IL-12p40-, IL12p40-, IL-12p40-KO, p40-
Gene: Il12b  Location: Chr11:44400063-44414033 bp, + strand  Genetic Position: Chr11, 25.94 cM, cytoband A5-B2
Germline Transmission:  Earliest citation of germline transmission: J:33141
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A neomycin resistance cassette replaced a portion of exon 3 of the gene. (J:33141)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 32 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Il12b Mutation:  22 strains or lines available
Original:  J:33141 Magram J, et al., IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses. Immunity. 1996 May;4(5):471-81
All:  340 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory