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Il12atm1Jm
Targeted Allele Detail
Nomenclature
Symbol: Il12atm1Jm
Name: interleukin 12a; targeted mutation 1, Jeanne Magram
MGI ID: MGI:1857200
Synonyms: Il12a-, Il12p35-, IL-12p35, IL-12p35-, p35-
Gene: Il12a  Location: Chr3:68690644-68698547 bp, + strand  Genetic Position: Chr3, 31.92 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:34164
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A neomycin resistance cassette replaced exons 1 and 2 of the gene. (J:34164)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Il12a Mutation:  23 strains or lines available
References
Original:  J:34164 Mattner F, et al., Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Eur J Immunol. 1996 Jul;26(7):1553-9
All:  183 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory