Il10^tm1Cgn
Targeted Allele Detail

Summary

• Symbol: Il10^tm1Cgn
• Name: interleukin 10; targeted mutation 1, University of Cologne
• MGI ID: MGI:1857199
• Synonyms: Il10-, IL-10-, IL-10KO, IL-10^KO, IL-10 KO, Il10^tmCgn
• Gene: Il10 Location: Chr1:130947582-130952711 bp, + strand Genetic Position: Chr1, 56.89 cM
• Alliance: Il10^tm1Cgn page

Characterization of Il10^tm1Cgn/Il10^tm1Cgn mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:15222
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 500 bp genomic fragment containing codons 5-55 was replaced with a linker containing a termination codon followed by a neomycin cassette. A termination codon was also introduced into exon 3. No IL10 activity was detectable by ELISA assays in supernatants of in vitro cultures of Con A-stimulated splenic T cells derived from homozygous mice following infection with the nematode N. brasiliensis. (J:15222)

Disease models

Expression

In Mice Carrying this Mutation:	8 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	26 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Il10^tm1Cgn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 15 strains available Cell Lines: 0 lines available
• Carrying any Il10 Mutation: 44 strains or lines available

References

• Original: J:15222 Kuhn R, et al., Interleukin-10-deficient mice develop chronic enterocolitis [see comments]. Cell. 1993 Oct 22;75(2):263-74
• All: 1005 reference(s)