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Il2ratm1Dw
Targeted Allele Detail
Nomenclature
Symbol: Il2ratm1Dw
Name: interleukin 2 receptor, alpha chain; targeted mutation 1, Dennis M Willerford
MGI ID: MGI:1857192
Synonyms: CD25-, CD25KO, IL-2Ralpha-, IL2Ralpha-, IL-2Ralpha KO
Gene: Il2ra  Location: Chr2:11642807-11693193 bp, + strand  Genetic Position: Chr2, 8.91 cM, cytoband A2-A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64279
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a 5.5 kb segment of the gene, containing exons 2 and 3, which encode for the binding site of the protein. (J:64279)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Il2ra Mutation:  19 strains or lines available
References
Original:  J:64279 Willerford DM, et al., Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity. 1995 Oct;3(4):521-30
All:  64 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory