Cd74^tm2Liz
Targeted Allele Detail

Summary

• Symbol: Cd74^tm2Liz
• Name: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); targeted mutation 2, Elizabeth K Bikoff
• MGI ID: MGI:1857190
• Synonyms: 31
• Gene: Cd74 Location: Chr18:60936921-60945724 bp, + strand Genetic Position: Chr18, 34.41 cM
• Alliance: Cd74^tm2Liz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28966
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Deletion of exon 6b results in expression of the p31 isoform but not p41. (J:28966)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd74 Mutation: 33 strains or lines available

References

• Original: J:28966 Takaesu NT, et al., Major histocompatibility class II peptide occupancy, antigen presentation, and CD4+ T cell function in mice lacking the p41 isoform of invariant chain. Immunity. 1995 Sep;3(3):385-96
• All: 7 reference(s)