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Ighmtm1Cgn
Targeted Allele Detail
Nomenclature
Symbol: Ighmtm1Cgn
Name: immunoglobulin heavy constant mu; targeted mutation 1, University of Cologne
MGI ID: MGI:1857187
Synonyms: B cell-, BCKO, BCR-, BKO, Cmu -, Ig-, IgH-, Igh-6-, Igh-6null, Igh-6tm1Cgn, Igh-6tm1CgnmuMT0, Ighm-, IgHmuMT, Ig- muMT, Igmunull, muIgKO, mum-, muMt-, muMT, mu-MT-
Gene: Ighm  Location: Chr12:113418558-113422730 bp, - strand  Genetic Position: Chr12, 62.1 cM, cytoband F1-2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70398
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette disrupted one of the membrane exons of the gene encoding immunoglobulin heavy chain of the class mu (IgM). (J:70398, J:110548)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 20 strains available      Cell Lines: 0 lines available
Carrying any Ighm Mutation:  32 strains or lines available
References
Original:  J:70398 Kitamura D, et al., A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature. 1991 Apr 4;350(6317):423-6
All:  584 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory