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Targeted Allele Detail
Symbol: Gfaptm1Mes
Name: glial fibrillary acidic protein; targeted mutation 1, Albee Messing
MGI ID: MGI:1857176
Gene: Gfap  Location: Chr11:102887336-102897200 bp, - strand  Genetic Position: Chr11, 66.48 cM, cytoband D
Germline Transmission:  Earliest citation of germline transmission: J:64290
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin cassette replaced most of exon 1 and all of exons 2-4. Northern blot analysis revealed that there was no mRNA produced from this allele in whole brain RNA samples derived from homozygous mice. Immunohistochemical studies detected no GFAP protein present in sections of hippocampus in homozygous mice. (J:64290)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 13 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gfap Mutation:  35 strains or lines available
Original:  J:64290 McCall MA, et al., Targeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiology. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6361-6
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory