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Gabra6tm1Geh
Targeted Allele Detail
Nomenclature
Symbol: Gabra6tm1Geh
Name: gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6; targeted mutation 1, Gregg E Homanics
MGI ID: MGI:1857173
Gene: Gabra6  Location: Chr11:42197264-42211899 bp, - strand  Genetic Position: Chr11, 25.03 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:40242
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin selection cassette was inserted into exon 8. Northern blot analysis on RNA derived from cerebellum of homozygous mice demonstrated that aberrant transcripts were expressed from this allele. Hoever, none of these are predicted to be able to code for a functional protein (J:40242). Later studies showed that this mutation also affected the expression of the Gabra1 and Gabrb2 genes (J:63792). (J:40242, J:63792)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gabra6 Mutation:  27 strains or lines available
References
Original:  J:40242 Homanics GE, et al., Gene knockout of the alpha6 subunit of the gamma-aminobutyric acid type A receptor: lack of effect on responses to ethanol, pentobarbital, and general anesthetics. Mol Pharmacol. 1997 Apr;51(4):588-96
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory