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Fmr1tm1Cgr
Targeted Allele Detail
Nomenclature
Symbol: Fmr1tm1Cgr
Name: fragile X mental retardation syndrome 1; targeted mutation 1, Ben Oostra
MGI ID: MGI:1857169
Synonyms: Fmr1 KO, Fmr1tm4Cgr, FMRP KO, fmr-tm1Cgr, FraX
Gene: Fmr1  Location: ChrX:68678541-68717963 bp, + strand  Genetic Position: ChrX, 34.83 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:19220
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance gene was inserted into exon 5. RT-PCR analysis on testis RNA derived from hemizygous male mice demonstrated that no detectable transcript was produced from this allele, and western blot analysis on extracts of testes, liver, kidney and brain of hemizygous male mice confirmed that no stable encoded protein was made. (J:19220)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 4 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Fmr1 Mutation:  21 strains or lines available
Notes
Genbank: AF179463 and AF170530

References
Original:  J:19220 Bakker CE, et al., Fmr1 knockout mice: a model to study fragile x mental retardation. The Dutch-Belgium Fragile X Consortium. Cell. 1994 Jul 15;78(1):23-33
All:  194 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory