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Fcgr2btm1Ttk
Targeted Allele Detail
Nomenclature
Symbol: Fcgr2btm1Ttk
Name: Fc receptor, IgG, low affinity IIb; targeted mutation 1, Toshiyuki Takai
MGI ID: MGI:1857166
Synonyms: FcgammaRII, FcgammaRII-, FcgammaRII2B-, FcgammaRIIb-, FcgammaRIIB-, Fcgr2btm1Rav, FcgRIIB129-, FcRIIB-, IIB-, TAC264
Gene: Fcgr2b  Location: Chr1:170958617-170976547 bp, - strand  Genetic Position: Chr1, 78.02 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:31133
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 2.3 kb genomic fragment containing the S1 and EC1 exons was replaced by a neomycin resistance cassette. Encoded transcript was undetectable in homozygous mutant mice via Northern blot analysis (data not shown). Western blot analysis of LPS-stimulated B cells derived from homozygous mice confirmed that no protein was made from this allele, and FACS analysis demonstrated that no functional protein was expressed on the cell surface of B cells in homozygous mice. (J:31133)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Fcgr2b Mutation:  17 strains or lines available
Notes

Phenotypic Similarity to Human Syndrome: Autoimmune Cystitis J:207275

References
Original:  J:31133 Takai T, et al., Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Nature. 1996 Jan 25;379(6563):346-9
All:  191 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory