Drd1^tm1Jcd
Targeted Allele Detail

Summary

• Symbol: Drd1^tm1Jcd
• Name: dopamine receptor D1; targeted mutation 1, John Drago
• MGI ID: MGI:1857158
• Synonyms: D1^-, D1A-, D1r^-
• Gene: Drd1 Location: Chr13:54205202-54209677 bp, - strand Genetic Position: Chr13, 28.4 cM
• Alliance: Drd1^tm1Jcd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:22076
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 0.75kb of sequence encoding the fifth transmembrane domain and third intracytoplasmic loop. (J:22076)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Drd1 Mutation: 68 strains or lines available

References

• Original: J:22076 Drago J, et al., Altered striatal function in a mutant mouse lacking D1A dopamine receptors. Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12564-8
• All: 69 reference(s)