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Dnmt1tm1Jae
Targeted Allele Detail
Summary
Symbol: Dnmt1tm1Jae
Name: DNA methyltransferase 1; targeted mutation 1, Rudolf Jaenisch
MGI ID: MGI:1857157
Synonyms: Dmntn, Dnmt1N, DnmtN, MTase(-), Mtasen
Gene: Dnmt1  Location: Chr9:20818501-20871084 bp, - strand  Genetic Position: Chr9, 7.66 cM
Alliance: Dnmt1tm1Jae page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:1157
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsReplacement of 900 bp, including the translation start site, with a neomycin cassette. This is a hypomorphic allele; enzyme activity levels have dropped to approximately 30% of the normal value. (J:1157)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 64 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Dnmt1tm1Jae
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Dnmt1 Mutation:  108 strains or lines available
References
Original:  J:1157 Li E, et al., Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell. 1992 Jun 12;69(6):915-26
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory