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Gzmbtm1Ley
Targeted Allele Detail
Nomenclature
Symbol: Gzmbtm1Ley
Name: granzyme B; targeted mutation 1, Timothy J Ley
MGI ID: MGI:1857156
Synonyms: Granzyme B-, GrB KO, GrzB-, gzmB-, Gzmb-, Gzmb-/+PGK-neo
Gene: Gzmb  Location: Chr14:56258856-56262260 bp, - strand  Genetic Position: Chr14, 28.19 cM, cytoband D3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:23560
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin resistance cassette replaced a 350bp AvrII fragment starting within the 5' untranslated region (22 bp upstream from the initiation codon), extending through exon 1 and part of intron 1. (J:23560)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Gzmb Mutation:  7 strains or lines available
References
Original:  J:23560 Heusel JW, et al., Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell. 1994 Mar 25;76(6):977-87
All:  73 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory