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Targeted Allele Detail
Symbol: Cd28tm1Mak
Name: CD28 antigen; targeted mutation 1, Tak Mak
MGI ID: MGI:1857150
Synonyms: CD28-, CD28KO
Gene: Cd28  Location: Chr1:60716800-60773359 bp, + strand  Genetic Position: Chr1, 30.52 cM, cytoband C1-C3
Germline Transmission:  Earliest citation of germline transmission: J:14194
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing part of exon 2 was replaced by a neomycin resistance cassette. Flow-cytometry analysis on peripheral blood lymphocytes demonstrated that the protein was not expressed in these cells in homozygous mice. (J:14194)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 7 strains available      Cell Lines: 0 lines available
Carrying any Cd28 Mutation:  22 strains or lines available
Original:  J:14194 Shahinian A, et al., Differential T cell costimulatory requirements in CD28-deficient mice. Science. 1993 Jul 30;261(5121):609-12
All:  270 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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