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Cdkn1btm1Mlf
Targeted Allele Detail
Nomenclature
Symbol: Cdkn1btm1Mlf
Name: cyclin-dependent kinase inhibitor 1B; targeted mutation 1, Matthew Fero
MGI ID: MGI:1857146
Synonyms: Cdkln1btm1Mlf, p27-, p27Kip1, p27Kip1-, p27kip1-null
Gene: Cdkn1b  Location: Chr6:134920401-134925513 bp, + strand  Genetic Position: Chr6, 65.77 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33400
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Replacement of the entire coding region of the Cdkn1b gene with a neomycin cassette. (J:33400)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 14 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cdkn1b Mutation:  11 strains or lines available
References
Original:  J:33400 Fero ML, et al., A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell. 1996 May 31;85(5):733-44
All:  112 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory