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Cdkn1btm1Mlf
Targeted Allele Detail
Summary
Symbol: Cdkn1btm1Mlf
Name: cyclin-dependent kinase inhibitor 1B; targeted mutation 1, Matthew Fero
MGI ID: MGI:1857146
Synonyms: Cdkln1btm1Mlf, p27-, p27Kip1, p27Kip1-, p27kip1-null
Gene: Cdkn1b  Location: Chr6:134897364-134902476 bp, + strand  Genetic Position: Chr6, 65.77 cM
Alliance: Cdkn1btm1Mlf page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33400
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Replacement of the entire coding region of the Cdkn1b gene with a neomycin cassette. (J:33400)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 14 assay results
In Structures Affected by this Mutation: 12 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Cdkn1btm1Mlf
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cdkn1b Mutation:  20 strains or lines available
References
Original:  J:33400 Fero ML, et al., A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell. 1996 May 31;85(5):733-44
All:  141 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory