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Targeted Allele Detail
Symbol: Bdnftm1Jae
Name: brain derived neurotrophic factor; targeted mutation 1, Rudolf Jaenisch
MGI ID: MGI:1857136
Synonyms: BDNF-, BDNF-KO
Gene: Bdnf  Location: Chr2:109674700-109727007 bp, + strand  Genetic Position: Chr2, 56.63 cM
Germline Transmission:  Earliest citation of germline transmission: J:17123
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA part of exon 5 of the gene was deleted and replaced by a neomycin cassette. This deletion left 49 and 30 amino acids in the N and C termini, respectively. Northern blot analysis on RNA derived from cerebral cortex showed that no detectable transcript is expressed from this allele. (J:17123)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 14 assay results
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Bdnf Mutation:  31 strains or lines available
Original:  J:17123 Ernfors P, et al., Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature. 1994 Mar 10;368(6467):147-50
All:  142 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory