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B2mtm1Unc
Targeted Allele Detail
Nomenclature
Symbol: B2mtm1Unc
Name: beta-2 microglobulin; targeted mutation 1, University of North Carolina
MGI ID: MGI:1857133
Synonyms: b2mnull, beta2M-, beta2m0, beta2-m-KO, beta2MKO, beta2mnull, beta2mo, beta2mtm1Unc, I0, MHC-I-
Gene: B2m  Location: Chr2:122147687-122153082 bp, + strand  Genetic Position: Chr2, 60.55 cM, cytoband F1-F3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65612
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    Insertion of a neomycin-resistance gene into the second exon. (J:65612)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 38 strains available      Cell Lines: 0 lines available
Carrying any B2m Mutation:  67 strains or lines available
References
Original:  J:65612 Koller BH, et al., Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination. Proc Natl Acad Sci U S A. 1989 Nov;86(22):8932-5
All:  468 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory