About   Help   FAQ
Atmtm1Awb
Targeted Allele Detail
Summary
Symbol: Atmtm1Awb
Name: ataxia telangiectasia mutated; targeted mutation 1, Anthony Wynshaw Boris
MGI ID: MGI:1857132
Synonyms: Atm-, ATM-, Atmins5790neo, Atmtm1Awbl
Gene: Atm  Location: Chr9:53350449-53448040 bp, - strand  Genetic Position: Chr9, 29.12 cM, cytoband C-D
Alliance: Atmtm1Awb page
Oxidated stress in the brain of Atmtm1Awb/Atmtm1Awb mice indicated by increased levels of heme oxygenase

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:34193
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Humanized sequence, Null/knockout)
Mutation:    Insertion
 
Mutation detailsA PGK-neomycin cassette was inserted into position 5979 of the Atm gene. This mutation results in a truncated protein, and the position of the mutation corresponds to the location of truncation mutations known to exist in humans. (J:34193)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Mice Carrying this Mutation: 39 assay results
In Structures Affected by this Mutation: 10 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Atmtm1Awb
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 7 strains available      Cell Lines: 0 lines available
Carrying any Atm Mutation:  126 strains or lines available
References
Original:  J:34193 Barlow C, et al., Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell. 1996 Jul 12;86(1):159-71
All:  225 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
11/22/2022
MGI 6.22
The Jackson Laboratory