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Alpltm1Sor
Targeted Allele Detail
Nomenclature
Symbol: Alpltm1Sor
Name: alkaline phosphatase, liver/bone/kidney; targeted mutation 1, Philippe Soriano
MGI ID: MGI:1857124
Synonyms: Tnap-, TN-APBetageo, TNAP-bgeo
Gene: Alpl  Location: Chr4:137741733-137796384 bp, - strand  Genetic Position: Chr4, 70.02 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:25249
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Alpl Mutation:  326 strains or lines available
Notes
Only the embryonic (EAP) and tissue non-specific (TNAP) forms of alkaline phosphatase are expressed in mouse embryos. EAP is the predominant form of the enzyme in the early embryo, but predominance switches to TNAP about the 7th embryonic day. Akp2tm1Sor was used to clarify the expression of TNAP in mouse primordial germ cells. These cells do not express TNAP before gastrulation, but the enzyme is elaborated by extraembryonic tissue prior to that stage. Primordial germ cells do not require TNAP for either development or migration (J:25249).

References
Original:  J:25249 MacGregor GR, et al., Tissue non-specific alkaline phosphatase is expressed in both embryonic and extraembryonic lineages during mouse embryogenesis but is not required for migration of primordial germ cells. Development. 1995 May;121(5):1487-96
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory