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Adatm1Mw
Targeted Allele Detail
Summary
Symbol: Adatm1Mw
Name: adenosine deaminase; targeted mutation 1, Maki Wakamiya
MGI ID: MGI:1857117
Synonyms: Ada-, adam1
Gene: Ada  Location: Chr2:163568504-163592159 bp, - strand  Genetic Position: Chr2, 84.44 cM, cytoband H3
Alliance: Adatm1Mw page
Hepatocyte abnormalities in Adatm1Mw/Adatm1Mw mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:25085
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin selection cassette was inserted into exon 5. Activity assays demonstrated that no functional protein was made from this allele in homozygous mice. (J:25085)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 20 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Ada Mutation:  21 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Pulmonary Hypertension associated with Chronic Obstructive Pulmonary Disease J: 231559.
References
Original:  J:25085 Wakamiya M, et al., Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice. Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3673-7
All:  44 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory