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Targeted Allele Detail
Symbol: Acetm2Unc
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; targeted mutation 2, University of North Carolina
MGI ID: MGI:1857116
Synonyms: sTsT
Gene: Ace  Location: Chr11:105858774-105880790 bp, + strand  Genetic Position: Chr11, 68.84 cM
Germline Transmission:  Earliest citation of germline transmission: J:46177
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Modified isoform(s))
Mutations:    Insertion, Intragenic deletion
Mutation detailsThis mutation eliminates expression of the somatic isoform of the protein but does not affect expression of the testicular isoform. A short genomic fragment extending from the beginning of exon 10 to intron 10 was replaced with a neomycin selection cassette in the oppostie transcriptional orientation to the gene. (J:46177)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ace Mutation:  36 strains or lines available
Original:  J:46177 Hagaman JR, et al., Angiotensin-converting enzyme and male fertility. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2552-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.19
The Jackson Laboratory