Whrn^wi
Spontaneous Allele Detail

Summary

• Symbol: Whrn^wi
• Name: whirlin; whirler
• MGI ID: MGI:1857090
• Synonyms: wi
• Gene: Whrn Location: Chr4:63333147-63414228 bp, - strand Genetic Position: Chr4, 33.97 cM, cytoband C1
• Alliance: Whrn^wi page

Mutation origin

• Strain of Origin: STOCK a Tyrp1^b Myo5a^d Oca2^p Ednrb^s

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• Mutation details: The mutation was identified as a 526 bp deletion encompassing the first putative methionine of the short C-terminal isoform and part of the long isoform. This creates a frameshift resulting in premature termination of the long isoform before the third PDZ domain. This deletion encompasses the majority of exons 6-10 of the gene, thus resulting in the ablation of both the long (WHRN-L) and the short (WHRN-S) isoforms. (J:86904, J:235390)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Whrn Mutation: 43 strains or lines available

Notes

They have defects of the membranous labyrinth similar to those of Myo15 (M.S. Deol, personal communication).

References

• Original: J:269 Lane PW, Whirler mice, a recessive behavior mutation in linkage group VIII. J Hered. 1963 Nov-Dec;54:263-6
• All: 29 reference(s)