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Whrnwi
Spontaneous Allele Detail
Nomenclature
Symbol: Whrnwi
Name: whirlin; whirler
MGI ID: MGI:1857090
Synonyms: wi
Gene: Whrn  Location: Chr4:63414910-63495991 bp, - strand  Genetic Position: Chr4, 33.97 cM, cytoband C1
Mutation
origin
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
 
Mutation detailsThe mutation was identified as a 526 bp deletion encompassing the first putative methionine of the short C-terminal isoform and part of the long isoform. This creates a frameshift resulting in premature termination of the long isoform before the third PDZ domain. This deletion encompasses the majority of exons 6-10 of the gene, thus resulting in the ablation of both the long (WHRN-L) and the short (WHRN-S) isoforms. (J:86904, J:235390)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Whrn Mutation:  13 strains or lines available
Notes
They have defects of the membranous labyrinth similar to those of Myo15 (M.S. Deol, personal communication).
References
Original:  J:269 Lane PW, Whirler mice, a recessive behavior mutation in linkage group VIII. J Hered. 1963 Nov-Dec;54:263-6
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory