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Wnt3avt
Spontaneous Allele Detail
Nomenclature
Symbol: Wnt3avt
Name: wingless-type MMTV integration site family, member 3A; vestigial tail
MGI ID: MGI:1857088
Synonyms: vt
Gene: Wnt3a  Location: Chr11:59248036-59290751 bp, - strand  Genetic Position: Chr11, 37.17 cM
Wnt3avt/Wnt3avt

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BR
Mutation
description
Allele Type:    Spontaneous (Hypomorph)
Mutation:    Undefined
 
Mutation detailsExamination of the Wnt3a gene by Southern blot, Northern blot on adult lung tissue and cDNA sequence analysis revealed no sign of an obvious mutation that could account for a mutant phenotype. However, this mutation and a targeted mutation, Wnt3atm1Amc, were demonstrated to be noncomplemeting alleles. Further evidence from whole mount in situ hybridization studies on embryos demonstrated that expression of the encoded protein is reduced in homozygous embryos, suggesting that this hypomorphic allele results from a mutation in a regulatory element. (J:31335)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 39 assay results
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Wnt3a Mutation:  23 strains or lines available
References
Original:  J:64271 Heston WE, vt - vestigial-tail. Mouse News Lett. 1951;4:11
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory