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Foxp3sf
Spontaneous Allele Detail
Nomenclature
Symbol: Foxp3sf
Name: forkhead box P3; scurfy
MGI ID: MGI:1857034
Synonyms: Scurfy, sf
Gene: Foxp3  Location: ChrX:7579676-7595243 bp, + strand  Genetic Position: ChrX, 3.41 cM
Mutation
origin
Strain of Origin:  STOCK MR
Mutation
description
Allele Type:    Spontaneous
Mutation:    Insertion
 
Mutation detailsInsertion of two adenosine residues into exon 8, resulting in a 2 bp shift in the reading frame. This allele is predicted to produce a truncated protein lacking the carboxy-terminal forkhead domain. (J:66695)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 33 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Foxp3 Mutation:  41 strains or lines available
References
Original:  J:13126 Russell WL, et al., Exceptional inheritance of a sex-linked gene in the mouse explained on the basis that the X/O sex-chromosome constitution is female. Proc Natl Acad Sci U S A. 1959 Apr;45(4):554-560
All:  112 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory