Dll3^pu
Radiation induced Allele Detail

Summary

• Symbol: Dll3^pu
• Name: delta like canonical Notch ligand 3; pudgy
• MGI ID: MGI:1857008
• Synonyms: pu
• Gene: Dll3 Location: Chr7:27992980-28001210 bp, - strand Genetic Position: Chr7, 16.67 cM
• Alliance: Dll3^pu page

control and Dll3^pu/Dll3^pu

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: (101/Rl x C3H/Rl)F1

Mutation description

• Allele Type: Radiation induced
• Mutation: Intragenic deletion
• Mutation details: Sequencing of Dll3 shows that Dll3^pu mutants have a 4 bp deletion in the third exon leading to a frameshift and early truncation of the expected Dll3 product ahead of the conserved DSL domain. (J:48518)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	80 assay results
In Structures Affected by this Mutation:	16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dll3 Mutation: 40 strains or lines available

Notes

The pudgy mutation appeared in descendants of an X-rayed male at the Oak Ridge National Laboratory. (J:14975). It has been suggested that Dll3^pu may be a recurrence of stub (sb), a skeletal mutant now extinct (J:245).

References

• Original: J:14975 Gruneberg H, Genetical studies on the skeleton of the mouse. XXIX. Pudgy. Genet Res. 1961;2(3):384-93
• All: 18 reference(s)