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Dock7m
Spontaneous Allele Detail
Nomenclature
Symbol: Dock7m
Name: dedicator of cytokinesis 7; misty
MGI ID: MGI:1856946
Synonyms: m
Gene: Dock7  Location: Chr4:98936675-99120860 bp, - strand  Genetic Position: Chr4, 45.6 cM, cytoband C6
Mutation
origin
Strain of Origin:  DBA/J
Mutation
description
Allele Type:    Spontaneous
Mutation:    Insertion
 
Mutation detailsCrosses between mice homozygous for misty and for moonlight, which mapped to overlapping critical regions on Chr 4, demonstrated failure of the two mutations to complement one another. Once moonlight had been identified as a mutation of Dock7 (Dock7mnlt), sequence analysis of this gene from misty mice revealed a retrotransposon LTR insertion following nucleotide 2045 (numbering from the A of the transcription initiation codon) that interrupts exon 18 and shifts the reading frame after codon 682 so that ten incorrect amino acids are incorporated into the protein before its premature termination. (J:146458)
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 10 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 11 strains available      Cell Lines: 0 lines available
Carrying any Dock7 Mutation:  16 strains or lines available
References
Original:  J:12159 Woolley GW, "Misty," a new coat color dilution in the mouse, Mus musculus. Am Naturalist. 1941;75:507-508
All:  50 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory