Dock7^m
Spontaneous Allele Detail

Summary

• Symbol: Dock7^m
• Name: dedicator of cytokinesis 7; misty
• MGI ID: MGI:1856946
• Synonyms: m
• Gene: Dock7 Location: Chr4:98824908-99009152 bp, - strand Genetic Position: Chr4, 45.6 cM, cytoband C6
• Alliance: Dock7^m page

Mutation origin

• Strain of Origin: DBA/J

Mutation description

• Allele Type: Spontaneous
• Mutation: Insertion
• Mutation details: Crosses between mice homozygous for misty and for moonlight, which mapped to overlapping critical regions on Chr 4, demonstrated failure of the two mutations to complement one another. Once moonlight had been identified as a mutation of Dock7 (Dock7^mnlt), sequence analysis of this gene from misty mice revealed a retrotransposon LTR insertion following nucleotide 2045 (numbering from the A of the transcription initiation codon) that interrupts exon 18 and shifts the reading frame after codon 682 so that ten incorrect amino acids are incorporated into the protein before its premature termination. (J:146458)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	10 assay results 7 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Dock7^m

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 14 strains available Cell Lines: 0 lines available
• Carrying any Dock7 Mutation: 111 strains or lines available

References

• Original: J:12159 Woolley GW, "Misty," a new coat color dilution in the mouse, Mus musculus. Am Naturalist. 1941;75:507-508
• All: 78 reference(s)