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Spontaneous Allele Detail
Symbol: Dock7m
Name: dedicator of cytokinesis 7; misty
MGI ID: MGI:1856946
Synonyms: m
Gene: Dock7  Location: Chr4:98824908-99009152 bp, - strand  Genetic Position: Chr4, 45.6 cM, cytoband C6
Strain of Origin:  DBA/J
Allele Type:    Spontaneous
Mutation:    Insertion
Mutation detailsCrosses between mice homozygous for misty and for moonlight, which mapped to overlapping critical regions on Chr 4, demonstrated failure of the two mutations to complement one another. Once moonlight had been identified as a mutation of Dock7 (Dock7mnlt), sequence analysis of this gene from misty mice revealed a retrotransposon LTR insertion following nucleotide 2045 (numbering from the A of the transcription initiation codon) that interrupts exon 18 and shifts the reading frame after codon 682 so that ten incorrect amino acids are incorporated into the protein before its premature termination. (J:146458)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 10 assay results
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 14 strains available      Cell Lines: 0 lines available
Carrying any Dock7 Mutation:  70 strains or lines available
Original:  J:12159 Woolley GW, "Misty," a new coat color dilution in the mouse, Mus musculus. Am Naturalist. 1941;75:507-508
All:  78 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory