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Nek8jck
Spontaneous Allele Detail
Nomenclature
Symbol: Nek8jck
Name: NIMA (never in mitosis gene a)-related expressed kinase 8; juvenile cystic kidney
MGI ID: MGI:1856919
Synonyms: jck, Nek8-
Gene: Nek8  Location: Chr11:78166106-78176675 bp, - strand  Genetic Position: Chr11, 46.74 cM, cytoband B5
Mutation
origin
Strain of Origin:  C57BL/6J Tg 147-9a
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsThe mutation in jck mice has been identified as a double nucleotide substitution (c.1341G>T and c.1343G>T). While c.1341G>T is a silent mutation in the last base of the leucine codon at position 447, the c.133G>T mutation in the second base of evolutionary conserved glycine codon 448 in the C-terminal domain of the protein results in it changing to valine (p.G448V). (J:79896)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 17 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nek8 Mutation:  8 strains or lines available
References
Original:  J:11885 Atala A, et al., Juvenile cystic kidneys (jck): a new mouse mutation which causes polycystic kidneys. Kidney Int. 1993 May;43(5):1081-5
All:  28 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/30/2021
MGI 6.16
The Jackson Laboratory