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Invsinv
Transgenic Allele Detail
Nomenclature
Symbol: Invsinv
Name: inversin; inversion of embryonic turning
MGI ID: MGI:1856915
Synonyms: inv, inv-
Gene: Invs  Location: Chr4:48279760-48431954 bp, + strand  Genetic Position: Chr4, 26.11 cM, cytoband B
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic
Mutations:    Duplication, Insertion, Intragenic deletion
 
Mutation details
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 36 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 8 strains available      Cell Lines: 0 lines available
Carrying any Invs Mutation:  12 strains or lines available
Notes
This is the only situs inversus mutation in which the asymmetries occur 100% of the time. Transgenic complementation studies demonstrated that the Invs gene alone corrects the inv mutation, and should be considered the gene responsible for the inv phenotype (J:49759, J:50117).

References
Original:  J:4934 Yokoyama T, et al., Reversal of left-right asymmetry: a situs inversus mutation [see comments]. Science. 1993 Apr 30;260(5108):679-82
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory