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Atcayji-hes
Spontaneous Allele Detail
Nomenclature
Symbol: Atcayji-hes
Name: ataxia, cerebellar, Cayman type; jittery hesitant
MGI ID: MGI:1856898
Synonyms: hes, jihes
Gene: Atcay  Location: Chr10:81204508-81230833 bp, - strand  Genetic Position: Chr10, 39.72 cM
Mutation
origin
Strain of Origin:  C3H/HeJ-Tyrc-a
Mutation
description
Allele Type:    Spontaneous
Mutation:    Transposon insertion
 
Mutation detailsThe mutation in the hesitant mouse has been identified as an IAP insertion in intron 1 that results in large aberrant transcripts and small amounts of normal transcript. (J:85793)
Inheritance:    Recessive
Schematic of the location of the IAP insertion generating the Atcayji-hes allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atcay Mutation:  16 strains or lines available
Notes
Homozygotes can be recognized at 14 days of age by their slightly smaller size and hesitant walking motion. From 3 weeks of age on, mutants' hindlimbs hesitate after lifting and then are placed flat on the surface and stiffly extended causing the posterior to rise. No body tremors, spasticity, or muscle degeneration is observed. Homozygotes of both sexes are fertile, although fertility in males may be reduced(J:1771).
References
Original:  J:1771 Sweet HO, Hesitant (hes). Mouse Genome. 1991;89(4):844
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory