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Prop1df
Spontaneous Allele Detail
Nomenclature
Symbol: Prop1df
Name: paired like homeodomain factor 1; Ames dwarf
MGI ID: MGI:1856842
Synonyms: Amesdf, df, DW, Prop1-
Gene: Prop1  Location: Chr11:50950806-50953757 bp, - strand  Genetic Position: Chr11, 30.95 cM
Mutation
origin
Strain of Origin:  Goodale large mice x pink-eyed stock
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsA T-to-C mutation results in a serine to proline substitution at position 83 (p.S83P) within the alpha1 helix in the homeodomain of the encoded peptide. (J:36967)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 123 assay results
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Prop1 Mutation:  7 strains or lines available
Notes
The Ames dwarf mutation arose spontaneously in descendants of a cross of the Goodale large mouse stock to a pink-eyed stock.
References
Original:  J:64260 Schaible RH, et al., df - Ames dwarf. Mouse News Lett. 1961;25:35
All:  118 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory