crz
Spontaneous Allele Detail

Summary

• Symbol: crz
• Name: control of early proliferation of Trypanosoma cruzi
• MGI ID: MGI:1856836
• Gene: crz Location: unknown
• Alliance: crz page

Mutation origin

• Strain of Origin: BXH2/TyJ

Mutation description

• Allele Type: Spontaneous
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any crz Mutation: 0 strains or lines available

Notes

Homozygotes are unable to control early proliferation of the Brazil strain of T. cruzi, as determined by parasite number in the blood 16 days after intraperitoneal infection. Both progenitor strains have very little proliferation within that period and F1 offspring of BXH-2 with both progenitor strains also have low proliferation. crz is distinct from Tnfrsf6, a gene that also causes susceptibility to T. cruzi (J:7654).

References

• Original: J:7654 Trischmann TM, Single locus in BXH-2 mice responsible for inability to control early proliferation of Trypanosoma cruzi. Infect Immun. 1984 Dec;46(3):658-62
• All: 1 reference(s)