Cftr^tm1Hgu
Targeted Allele Detail

Summary

• Symbol: Cftr^tm1Hgu
• Name: cystic fibrosis transmembrane conductance regulator; targeted mutation 1, MRC Human Genetics Unit
• MGI ID: MGI:1856710
• Synonyms: cf, cftr^m1HGU, Cftr^m1Hgu, Cftr^{TgH(neoim)1Hgu}, Cftr^{TgH(neoim)Hgu}, EDI
• Gene: Cftr Location: Chr6:18170686-18322767 bp, + strand Genetic Position: Chr6, 8.1 cM, cytoband A3
• Alliance: Cftr^tm1Hgu page

Generation 27 and 28 Cftr^tm1Hgu/Cftr^tm1Hgu mice exhibit focal hypertrophy of goblet cells

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:14614
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: An insertion of a vector into intron 9 that included exon 10 interrupted by a neomycin selection gene. RT-PCR analysis on tissues derived from homozygous mice demonstrated that a low level of wild-type transcript was produced from this allele by exon skipping (J:20037). (J:14614, J:20037)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cftr Mutation: 97 strains or lines available

References

• Original: J:14614 Dorin JR, et al., Cystic fibrosis in the mouse by targeted insertional mutagenesis [see comments]. Nature. 1992 Sep 17;359(6392):211-5
• All: 28 reference(s)