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Targeted Allele Detail
Symbol: Cftrtm1Hgu
Name: cystic fibrosis transmembrane conductance regulator; targeted mutation 1, MRC Human Genetics Unit
MGI ID: MGI:1856710
Synonyms: cf, cftrm1HGU, Cftrm1Hgu, CftrTgH(neoim)1Hgu, CftrTgH(neoim)Hgu, EDI
Gene: Cftr  Location: Chr6:18170687-18322768 bp, + strand  Genetic Position: Chr6, 8.1 cM, cytoband A3
Generation 27 and 28 Cftrtm1Hgu/Cftrtm1Hgu mice exhibit focal hypertrophy of goblet cells

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:14614
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsAn insertion of a vector into intron 9 that included exon 10 interrupted by a neomycin selection gene. RT-PCR analysis on tissues derived from homozygous mice demonstrated that a low level of wild-type transcript was produced from this allele by exon skipping (J:20037). (J:14614, J:20037)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cftr Mutation:  13 strains or lines available
Original:  J:14614 Dorin JR, et al., Cystic fibrosis in the mouse by targeted insertional mutagenesis [see comments]. Nature. 1992 Sep 17;359(6392):211-5
All:  15 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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