About   Help   FAQ
Ets1vs
Spontaneous Allele Detail
Nomenclature
Symbol: Ets1vs
Name: E26 avian leukemia oncogene 1, 5' domain; variable spotting
MGI ID: MGI:1856643
Gene: Ets1  Location: Chr9:32547517-32669116 bp, + strand  Genetic Position: Chr9, 17.97 cM
Mutation
origin
Strain of Origin:  C3HeB/FeJ
Mutation
description
Allele Type:    Spontaneous (Not Specified)
Mutation:    Single point mutation
 
Mutation detailsThe molecular lesion is a nucleotide G-to-A transition in exon 3 at nucleotide position 647 (or coding nucleotide 305) (RefSeq NM_011808.2), which results in a glycine to glutamate substitution at residue 102 (p.G102E) within the Pointed (PNT) domain of the encoded protein. Multiple sequence alignment showed that this glycine residue is highly conserved among different species. (J:226957)
Inheritance:    Recessive
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ets1 Mutation:  15 strains or lines available
References
Original:  J:14217 Spencer CA, et al., Variable spotting (vs). Mouse News Lett. 1988;81:71
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/23/2021
MGI 6.17
The Jackson Laboratory